Metabolic: hypokalemia pseudoprimary hyperaldosteronism. Musculoskeletal: muscle weakness (with hypokalemia), myopathies, rhabdomyolysis. Antihypertensives, diuretics: Might increase hypokalemic effects of some diuretics. Avoid administration with licorice. Corticosteroids (together with topicals): Could improve results. Digoxin: May induce hypokalemia; risk of digitalis toxicity. Avoid administration with licorice. Loratadine, procainamide, quinidine, other drugs that might prolong QT interval: May have additive effects. Spironolactone: Might block ulcer-healing and aldosterone-like results of licorice. Avoid administration with licorice. Licorice is contraindicated in patients with arrhythmias; CV, renal, or hepatic disease; or hypertension. Avoid using it in pregnant or breastfeeding patients; results are unknown. Use cautiously below medical supervision in elderly patients. Monitor for hypokalemia in the patient receiving diuretics. A single large dose of licorice is much less probably to cause toxicity than extended intake of smaller amounts. Alert Licorice poisoning could be insidious. Monitor for pseudoprimary hyperaldosteronism inflicting mineralocorticoid-like results (headache, lethargy, sodium and water retention, hypokalemia, hypertension, and heart failure).

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