The Role of Brain Glycogen In Supporting Physiological Function
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작성자 Sondra 댓글 0건 조회 7회 작성일 25-09-28 02:11필드값 출력
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I. Neurons and glia. J. Elec. Micro. Techol. Cater, H. L., Benham, C. D., and Sundstrom, L. E. (2001). Neuroprotective position of monocarboxylate transport during glucose deprivation in slice cultures of rat hippocampus. Cater, H. L., Chandratheva, A., Benham, C. D., Morrison, B., and Sundstrom, L. E. (2003). Lactate and glucose as power substrates during, and after, oxygen deprivation in rat hippocampal acute and cultured slices. Champe, P. C., and Harvey, R. A. (2008). Biochemistry. Baltimore, MD: Lippincott Williams & Wilkins. Choeiri, C., Staines, W., and Messier, C. (2002). Immunohistochemical localization and quantification of glucose transporters within the mouse mind. Choi, H. B., Gordon, G. R., Zhou, N., Tai, C., Rungta, R. L., Martinez, J., et al. 2012). Metabolic communication between astrocytes and neurons by way of bicarbonate-responsive soluble adenylyl cyclase. Clausen, T. (1992). Potassium and sodium transport and pH regulation. Can. J. Physiol. Pharmacol. Cryer, P. E. (2013). Mechanisms of hypoglycemia-related autonomic failure in diabetes. N. Engl. J. Med. Dalsgaard, M. K., Ogoh, S., Dawson, E. A., Yoshiga, C. C., Quistorff, B., and Secher, N. H. (2004). Cerebral carbohydrate price of physical exertion in people.
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Fatty acids and ketone our bodies are preferentially utilized by skeletal muscle, thereby sparing glucose for cells that depend totally on it, especially crimson blood cells and neurons. However, after approximately 18 hours of fasting, or during intense and prolonged exercise, glycogen shops change into insufficient. At this point, in the absence of carbohydrate intake, gluconeogenesis turns into critical. Its importance is additional highlighted by the truth that blood glucose ranges below 2 mmol/L can result in unconsciousness. Additionally, with out gluconeogenesis, pyruvate can be lost, reducing the body’s capacity to produce ATP through aerobic respiration, greater than 10 ATP molecules per pyruvate oxidized, making its conservation essential throughout energy stress. In increased animals, gluconeogenesis occurs in the liver, kidney cortex, and enterocytes. Quantitatively, the liver is the key site, producing about 90% of synthesized glucose, followed by the kidney cortex with round 10%. The liver’s key role is basically because of its dimension; actually, on a wet weight foundation, the kidney cortex produces more glucose than the liver.
The large prevalence of glycogen in skeletal muscles signifies that it is essential in offering a mechanism by which ATP rapidly could be produced in muscle cells, which display a high and quickly fluctuating energy turnover. The responses of muscle glycogen to such perturbations as train and weight-reduction plan are very nicely documented in research of people as well as numerous animal models (Bergström et al. 1967; Jensen & Richter, 2012). As well as, it has been understood for greater than half a century that the power of muscle to train is seriously compromised when the glycogen retailer is decreased to low levels, even when there's an abundance of other gasoline sources (Bergström et al. 1967). Thus, Hultman and co-workers demonstrated a robust correlation between muscle glycogen content and endurance capability during prolonged cycling train (Bergström et al. 1967) and an inability to proceed such exercise when the glycogen shops had been exhausted (Hermansen et al.